DeCaprio Lab - Merkel Cell Carcinoma, Polyomavirus, Cell Cycle Research
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    • The DREAM complex/Cell cycle
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    • ​James A. DeCaprio, MD
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                                            Jingwei Cheng

I am interested in transforming proteins and oncogenes targeted by small DNA tumor viruses including polyomaviruses. I am particularly interested in the interplay between two MAX network components in Merkel cell carcinoma oncogenesis: the MCPyV ST, L-MYC and P400 complex (SLaP) mediated transcriptional activation and the Polycomb Repressive Complex 1.6 (PRC1.6) mediated transcriptional repression. I am working on understanding how the m6A RNA methylation and PRMT5-mediated symmetric dimethylarginine (SDMA) formation on splicing factors safeguard proper splicing of proliferation-associated genes in cancers where MYC-driven global excess of pre-mRNA may overwhelm the splicing machinery. 

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©2020 DeCaprio Lab at Dana-Farber Cancer Institute
  • Home
  • Research
    • Merkel cell carcinoma
    • The DREAM complex/Cell cycle
  • People
    • ​James A. DeCaprio, MD
    • Lab Members
    • Alumni
    • Division of Molecular & Cellular Oncology
  • Publications
  • Resources
  • Support Us
  • Contact Us